Myocarditis is caused by infectious (coxsackie A and B viruses, Chagas disease) andimmune causes. Clinically, the patient may be asymptomatic or may suffer from acute heart failure or even dilated cardiomyopathy.
Definitions The study of the essential nature of disease, including symptoms/signs, patho-genesis, complications, and morphologic consequences including structural and functional alterations in cells, tissues, and organs The study of all aspects of the disease process focusing on the pathogenesis leading to classical structural changes (gross and histopathology) and molecu-lar alterations The etiology (cause) of a disease may be genetic or environmental. The pathogen-esis of a disease defines the temporal sequence and the patterns of cellular injurythat lead to disease. Morphologic changes of the disease process include both gross changes and microscopic changes. The clinical significance of a disease relates to its signs and symptoms, disease course including complications, and prognosis. Methods Used Gross examination of organs on exam questions has 2 major components: identify-ing the organ and identifying the...
SHOCK Shock is characterized by vascular collapse and widespread hypoperfusion of cells and tissue due to reduced blood volume, cardiac output, or vascular tone. The cel-lular injury is initially reversible; if the hypoxia persists, the cellular injury becomes irreversible, leading to the death of cells and the patient. Major Causes of Shock · Cardiogenic shock (pump failure) can be due to myocardial infarction, car-diac arrhythmias, pulmonary embolism, and cardiac tamponade. · Hypovolemic shock (reduced blood volume) can be due to hemorrhage, fluidloss secondary to severe burns, and severe dehydration. · Septic shock (viral or bacterial infection) causes cytokines to trigger vasodilatation and hy...
MALIGNANT NEOPLASMS Carcinoma of the breast is the most common cancer in women and affects 1 in 9 women in the United States. It is also the second most common cause of cancer death. The incidence is increasing and is higher in the United States than in Japan. Many risk factors have been identified. The incidence increases with the following factors: • Age • Unusually long/intense exposure to estrogens (long length of reproductive life, nulliparity, obesity, exogenous estrogens) • Presence of proliferative fibrocystic changes, especially atypical hyperplasia • First-degree relative with breast cancer Hereditary influences are thought to be involved in 5–10% of breast cancers, with important genes a...
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